|Year : 2021 | Volume
| Issue : 2 | Page : 85-91
The effect of combined Pilates and yoga training on insulin and leptin level in breast cancer survivors: A randomized clinical trial
, Ramin Shabani1
, Hamid Saeidi Saedi2, Shadi Dehghanzadeh3
1 Department of Exercise Physiology, Physical Education and Sport Sciences, Humanities Faculty, Rasht Branch, Islamic Azad University, Rasht, Iran
2 Departement of Radiotherapy, Guilan University of Medical Sciences, Rasht, Iran
3 Department of Nursing, Nursing and Midwifery Faculty, Rasht Branch, Islamic Azad University, Rasht, Iran
|Date of Submission||01-Aug-2020|
|Date of Acceptance||06-Apr-2021|
|Date of Web Publication||04-May-2021|
Prof. Ramin Shabani
Department of Exercise Physiology, Physical Education and Sport Sciences, Humanities Faculty, Rasht Branch, Islamic Azad University, Rasht
Source of Support: None, Conflict of Interest: None
Context: Elevated levels of insulin and leptin can be associated with poor prognosis in breast cancer patients. A safe and effective exercise protocol seems necessary as an adjuvant therapy in breast cancer patients.
Aims: This study aimed to assess the effect of concurrent yoga and Pilates training on insulin and leptin in breast cancer survivors.
Setting and Design: This study was a randomized clinical trial research with control group in a selected oncology and radiotherapy center in Rasht, Iran, in 2019.
Materials and Methods: This clinical trial was performed on thirty breast cancer survivors. The participants were allocated in exercise group (n = 15) and control group (n = 15) by simple randomly. Exercise group underwent 12 weeks of concurrent yoga and Pilates training, 3 sessions/week and 75 min of workout in each session. Every participant completed the demographic questionnaire. Weight, insulin, leptin, carcinoembryonic antigen (CEA), and cancer antigen 15-3 (CA 15-3) levels were measured before and after 12 weeks of exercise in both groups.
Statistical Analysis Used: Data were analyzed using descriptive statistics, one-way ANCOVA, and paired t-test and Wilcoxon.
Results: Mean score of weight in the exercise group decreased from 73.03 ± 16.75 to 69.92 ± 15.46 (P = 0.01), but in control group, there was no significant improvement (from 85.54 ± 11.7 to 85.27 ± 9.71). There was a significant decrease in leptin levels (from 33.70 ± 15.93 to 21.21 ± 15.37) in exercise group (P = 0.02). However, there was no significant effect on insulin (from 7.66 ± 2.96 to 10.67 ± 4.51), CEA, and CA 15-3 (P > 0.05).
Conclusion: Twelve weeks of concurrent yoga and Pilates training have positive effects on leptin levels in breast cancer survivors.
Keywords: Breast cancer, Insulin, Leptin, Pilates training, Yoga
|How to cite this article:|
Ebrahimpour S, Shabani R, Saedi H, Dehghanzadeh S. The effect of combined Pilates and yoga training on insulin and leptin level in breast cancer survivors: A randomized clinical trial. J Nurs Midwifery Sci 2021;8:85-91
|How to cite this URL:|
Ebrahimpour S, Shabani R, Saedi H, Dehghanzadeh S. The effect of combined Pilates and yoga training on insulin and leptin level in breast cancer survivors: A randomized clinical trial. J Nurs Midwifery Sci [serial online] 2021 [cited 2022 Jun 27];8:85-91. Available from: https://www.jnmsjournal.org/text.asp?2021/8/2/85/315425
| Introduction|| |
Brest cancer is the second most common cancer among women (25% of all cancer cases)., Epidemiological researches have shown that Iranian women diagnosed with breast cancer a decade earlier than women from other ethnicities and younger age at presentation is related with poor prognosis. Breast cancer treatment has various emotional and physical adverse effects such as fatigue, decreased aerobic capacity, weight gain, and hypertension. Obesity is an independent risk factor for breast cancer and its recurrence and can be an adverse effect of chemotherapy and surgery. One of the adipose tissue products is leptin. Leptin is a multifunctional polypeptide molecule which regulates food intake, inflammation, cell differentiation, and proliferation. Leptin is mainly synthesized not only by distant or local adipocytes but also by cancer-associated fibroblasts and plays an important role in breast tumorogenesis and control breast cancer manner as an endocrine, paracrine, and autocrine hormone.,,,, Leptin effects on breast cancer proliferation independently way and also through insulin signaling pathway. Obesity can lead to insulin resistance and hyperinsulinemia which is related to breast cancer recurrence and mortality.,, In addition to blood glucose control, insulin and insulin-like growth factor (IGF) regulate cell growth and proliferation., Even though obesity leads to insulin resistance, but breast cancer cells express higher levels of insulin receptors and they are more sensitive to insulin than normal breast cells.
Despite advances in early detection and treatment of breast cancer, 20%–30% of patients experience relapse or metastasis. Hence, monitoring the progression or recurrence of the disease seems necessary in any intervention. A noninvasive tool for assessing progression or relapse of malignancies is tumor markers. In breast cancer, carcinoembryonic antigen (CEA) and cancer antigen 15-3 (CA 15-3) are the most widely used serum tumor markers., CEA is from immunoglobulin family and involve in cell adhesion. Normally, it presents as very low levels in blood but can increase in specific malignancies., CA 15-3 is a mucinous glycoprotein (also known as MUC-1) and exist in all epithelial cell membranes but CA 15-3 serum levels increase in breast cancer., Previous researches estimate the sensitivity and specificity of CEA 56.7% and 92%, respectively, and for CA 15-3 44.5% and 84.5%, respectively, for diagnosis of breast cancer recurrence and progression.
Exercise is an adjuvant therapy for breast cancer, and different researches have shown that it has no side effects or cancer survivors at any dose, type, or timing. Exercise increases energy consumption and reduces adipose tissue, therefore reduces leptin synthesis. Possible mechanisms of exercise for hyperinsulinemia improvement are increasing postsynaptic insulin receptors, increasing glucose transporter proteins, reducing secretion and clearance of free fatty acids, increasing glucose delivery to muscles, and promoting muscle tendency to glucose.
Breast cancer survivors have poor compliance for continuous exercise training but gentler training such as Yoga and Tai Chi have shown to be improve regular attendance. Pilates exercise is focus on breathing, endurance, and body control., Yoga is a mind–body exercise which can promote muscular strength, energy, and relaxation. These exercises can reduce adipose tissue and improve insulin sensitivity through better oxygenation and intermittent muscular contraction. However, the most effective duration and intensity of exercise training is still controversial. The chronic process of breast cancer, frequent hospitalization, poor general condition, and inactivity decrease the aerobic and anaerobic capacity in patients so an easy, safe, cheap, and effective exercise program can lead to changes in lifestyle and promote patients' prognosis and general health. It is also important to choose a safe intervention so control the relapse and metastasis during intervention through measuring breast cancer tumor markers seems reasonable. This research was conducted with the aim of investigating the effect of combined Pilates and yoga training on insulin and leptin level in breast cancer survivors.
| Materials and Methods|| |
This study was a randomized clinical trial conducted in a selected oncology and radiotherapy center in Rasht, Iran, in 2019. The present study has been registered with code “IRCT20150531022498N34” in the Iranian Registry of Clinical Trials and approved by Ethical Committee of Azad University, Lahijan Branch with code “IR.IAU.LIAU.REC.1399.008.”
The participants were breast cancer survivors referring to a selected oncology and radiotherapy center in Rasht, Iran. The inclusion criteria were age between 35 and 50 years old, breast cancer survivors undergoing partial mastectomy, termination of chemotherapy and radiotherapy for at least 6 months, ability to perform exercise trainings, and the approval of their oncologist for safety of this kind of intervention on their patients. The exclusion criteria were consist of more than 3 consecutive sessions or four intermittent sessions absence from the training, injury during training, and lack of interest in continuing the training.
Sample size was estimated with G*Power software 126.96.36.199 (t-test; α = 0.05; β = 0.80; Cohen's D = 0.95; df = 28)., Thirty breast cancer survivors were selected through availability sampling and were allocated by simple randomly using sequentially numbered containers to control and exercise groups. Patients were matched based on their disease stage and their treatment protocol. Each group had 15 people.
Exercise group performed 12 weeks of combined yoga and Pilates training, three sessions per week, 75 min each session.,, Exercise program was taught both individually and in groups by an exercise physiologist professor. The exercise training consists of 10 min warming up, 30 min Pilates training, 30 min yoga training, and 5 min cooling down. Pilates training consists of spine stretch, the saw, mermaid, oblique roll up, hundreds, one leg stretch, two leg stretch, scissors, shoulder bridge, hip twist, clam, arm opening, sidekick, and swan dive. Yoga training consists of six rounds of Tadasana, Upward salute pose, Uttanasana, Hadrasana, Dandasana, Knees, chest, and chin pose, Cobra pose, Urdhva Mukha Svansana, and repetition of Tadasana, Upward salute pose, Uttanasana and Hadrasana. Control group was advised to do their routine daily activities.
All participants attend to the program with complete awareness and satisfaction and all of them signed a written consent. Every participant in both groups was free to leave the program if they willing to do so.
Before the program, every participant completed a demographic form consisted of age, marital status, number of children, occupational and educational status, history of surgery, chemotherapy and radiotherapy, and disease duration. Before and after 12 weeks of training, weight (by using Soehnle scales made in China) and levels of insulin and leptin hormones and CEA and CA 15-3 tumor markers were measured. For blood analysis, 5 ml blood was obtained from bracial vein between 7 and 9 am. All blood samples from exercise group obtained a day before first training session and 24 h after last training session and after at least 8 h fasting (blood samples from control group were obtained in the same day as exercise group). Samples were obtained with venoject, mixed with heparin to prevent blood clotting, and centrifuged immediately. All samples were stored at −28°C until further analysis. Leptin levels were measured using medignost kit (Germany). Insulin levels were determined using Dia plusinc kit (Canada). CEA levels were measured using CanAg CEA EIA kit (Sweden). CA 15-3 levels were measured using CanAg CA 15-3 EIA kit (Sweden). All samples were measured with ELISA auto-analyzer (Stat Fax 303 pluse, ELISA Awarness, USA). All samples were measured in a same laboratory before and after the intervention.
Primary outcomes were changes in insulin and leptin levels and secondary outcomes were changes in tumor marker levels following intervention. For the exact analysis, mean, standard deviation, and median were reported for quantitative data, and frequency was reported for qualitative data. Shapiro–Wilk test was used to assess the normal distribution. Parametric data were evaluated by one-way ANCOVA and paired t-test, and nonparametric data were evaluated by Wilcoxon applied by SPSS software 25 (Chicago, Illinois, USA). P < 0.05 was considered statistically significant.
| Results|| |
The samples entered in this study included breast cancer survivors. From control group, four participants did not attend for the final evaluation, and from exercise group, two participants were absent in four intermittent sessions. Therefore, they were excluded from the study. Finally, the exercise group was consisting of 13 participants and control group was consisting of 11 participants [Chart 1]. The results of Shapiro–Wilk test showed that insulin, CEA, and CA 15-3 were followed the normal distribution, while weight and leptin did not follow the normal distribution. The demographic hormones and tumor markers' data of participants are described in [Table 1].
|Table 1: The comparison of the mean and standard deviation of the demographic, hormones, and tumor markers data before the intervention with exercise and control groups|
Click here to view
At the beginning of study, the insulin, CA 15-3, and CEA levels were significantly different in exercise and control group. Levene's test was demonstrated that the variance of insulin (P = 0.881; F = 0.02), CA 15-3 (P = 0.27; F = 0.63), and CEA (P = 0.460; F = 0.56) in two groups was equal. Therefore, we used the ANCOVA test and consider the pretest data as covariates to eliminate the effect of pretest data on the results of our analysis. The research finding indicated that weight and leptin levels were significantly decreased in exercise group after 12 weeks of combined yoga and Pilates training (P = 0.01 and P = 0.02, respectively), but there was not any significant changes in insulin levels (P = 0.16). Furthermore, no significant changes were seen in CA 15-3 and CEA levels (P = 0.60 and P = 0.21, respectively) [Table 2], [Table 3], [Table 4].
|Table 2: The comparison of the mean and standard deviation of insulin, cancer antigen 15-3, and carcinoembryonic antigen before and after the intervention with exercise and control groups|
Click here to view
|Table 3: The comparison of the mean and standard deviation of insulin, cancer antigen 15-3, and carcinoembryonic antigen before and after the intervention with exercise and control groups|
Click here to view
|Table 4: The comparison of the mean and standard deviation of weight and leptin before and after the intervention with exercise and control groups|
Click here to view
| Discussion|| |
The findings of this study showed that, after 12 weeks of combined Pilates and yoga exercises, weight and leptin levels have significantly decreased.
Obesity is associated with metabolic syndrome and can cause elevation in insulin and IGF levels. Chronic release of free fatty acid from adipose tissue is also lead to increased insulin, leptin, interleukin-6, and tumor necrosis factor-α secretion. Leptin activates several intracellular signaling pathways such as Janus kinase 2-signal transducer and activator of transcription 3 (JAK2-STAT3), mitogen-activated protein kinase, and phosphatidyl inositol 3-kinase-protein kinase B (PI3K-AKT) pathways,, which are involved in cell proliferation and apoptosis. Different studies have shown that over secretion of leptin can be associated with breast cancer occurrence and overexpression of its receptor in tumoral cells can be associated with metastasis.,
Some researches result in decreasing of leptin levels following 12-week walking in women with breast cancer. However, in contrast with the present study, some showed that there were no significant changes in leptin levels after 12 weeks of Pilates training or combination of diet and aerobic exercise., The different intensity of exercise protocol performed in this study could be the reason of its different results from the present study. Chronic exercise can decrease the fat storage and adipose tissue is known to be the main source of leptin. Exercise can also establish a new set point and promote the sensitivity of leptin receptors.
A clinical trial showed that moderate intensity aerobic exercise had no significant effect on serum insulin levels. However, in contrast with the present study, some studies showed that 2 weeks of Pilates exercises can reduce serum insulin in women. Another study has demonstrated that 4 months of moderate-intensity combined training had a significant effect on serum insulin in breast cancer survivors. Furthermore, another study showed that 3 months of aerobic exercise significantly reduced insulin levels in women surviving breast cancer. A randomized clinical trial on diabetic patients showed a significant reduction of insulin following 8 weeks aerobic training. This discrepancy could be due to different types, intensity, and duration of exercise training protocols. Intermittent muscle contraction during exercise lead to glucose consumption followed by reduction in insulin production. Exercise also promotes glucose sensitivity through increasing tissue perfusion and oxygenation. Tumor markers were measured to confirm that this kind of intervention is safe in breast cancer survivors and is not associated with relapse or metastasis of the disease.
One of the limitations of this project was the small number of samples, limited period of intervention, and short-term follow-up. Furthermore, due to variation of insulin and tumor marker levels in different menstrual cycle and their interaction with sexual hormones, we suggest considering menstrual phase and sexual hormone levels in future studies and following up participants for long-term effects of exercise training.
| Conclusion|| |
Based on the findings obtained in this study, we conclude that weight and leptin might be involved in breast cancer proliferation modulated by regular concurrent Pilates and yoga exercise. However, there was no significant effect on insulin. As Yoga and Pilates training are safe, cheap, and available even at home and according to their potential effects on regulating body metabolism, it seems reasonable to concentrate more on these kinds of exercises in breast cancer survivors.
Conflicts of interest
There are no conflicts of interest.
R. Shabani was involved in conducting the research and collecting the parts together, drafting the article, H. Saeidi doing the visits and, following up process with the patients, S. Ebrahimpour collecting data, S. Dehghanzade doing data analysis and revising the article critically.
Financial support and sponsorship
This study was financially supported by Rasht Branch, Islamic Azad University.
The researchers would like to thank the staff of Guilan Radiotherapy and Oncology clinic and Dr. Borzu and his colleagues in Gil. Our thanks also go to the patients who actively cooperated in the research process.
| References|| |
Liu FC, Lin HT, Kuo CF, See LC, Chiou MJ, Yu HP. Epidemiology and survival outcome of breast cancer in a nationwide study. Oncotarget 2017;8:16939-50.
Wild CP, Stewart BW, Wild C. World Cancer Report 2014. Geneva, Switzerland: World Health Organization; 2014.
Maryam A, Arezoo S, Arash K, Alsadat EP. Causes of breast cancer in women. J Res Med Dent Sci 2018;6:365-8.
Wilson DJ. Exercise for the patient after breast cancer surgery. Semin oncol nurs 2017;33:98-105.
Zhang Y, Chua S Jr. Leptin function and regulation. Comprehens Physiol 2011;8:351-69.
Andò S, Catalano S. The multifactorial role of leptin in driving the breast cancer microenvironment. Nat Rev Endocrinol 2011;8:263-75.
Andò S, Barone I, Giordano C, Bonofiglio D, Catalano S. The multifaceted mechanism of leptin signaling within tumor microenvironment in driving breast cancer growth and progression. Front Oncol 2014;4:340.
Barone I, Giordano C, Bonofiglio D, Andò S, Catalano S. Leptin, obesity and breast cancer: Progress to understanding the molecular connections. Curr Opin Pharmacol 2016;31:83-9.
Giordano C, Barone I, Vircillo V, Panza S, Malivindi R, Gelsomino L, et al
. Activated FXR inhibits leptin signaling and counteracts tumor-promoting activities of cancer - Associated fibroblasts in breast malignancy. Sci Rep 2016;6:21782.
Barone I, Catalano S, Gelsomino L, Marsico S, Giordano C, Panza S, et al
. Leptin mediates tumor-stromal interactions that promote the invasive growth of breast cancer cells. Cancer Res 2012;72:1416-27.
Giordano C, Chemi F, Panza S, Barone I, Bonofiglio D, Lanzino M, et al
. Leptin as a mediator of tumor-stromal interactions promotes breast cancer stem cell activity. Oncotarget 2016;7:1262-75.
Sánchez-Jiménez F, Pérez-Pérez A, de la Cruz-Merino L, Sánchez-Margalet V. Obesity and breast cancer: Role of leptin. Frontiers Oncol 2019;9:596.
Goodwin PJ, Ennis M, Pritchard KI, Trudeau ME, Koo J, Madarnas Y, et al
. Fasting insulin and outcome in early-stage breast cancer: Results of a prospective cohort study. J Clin Oncol 2002;20:42-51.
Calori G, Lattuada G, Piemonti L, Garancini MP, Ragogna F, Villa M, et al
. Prevalence, metabolic features, and prognosis of metabolically healthy obese Italian individuals: The Cremona study. Diabetes Care 2011;34:210-5.
Duggan C, Irwin ML, Xiao L, Henderson KD, Smith AW, Baumgartner RN, et al
. Associations of insulin resistance and adiponectin with mortality in women with breast cancer. J Clin Oncol 2011;29:32-9.
Kang C, LeRoith D, Gallagher EJ. Diabetes, obesity, and breast cancer. Endocrinology 2018;159:3801-12.
Lumeng CN, Saltiel AR. Inflammatory links between obesity and metabolic disease. J Clin Invest 2011;121:2111-7.
Lorusso G, Rüegg C. New insights into the mechanisms of organ-specific breast cancer metastasis. Semin Cancer Biol 2012;22:226-33.
Bidard FC, Hajage D, Bachelot T, Delaloge S, Brain E, Campone M, et al
. Assessment of circulating tumor cells and serum markers for progression-free survival prediction in metastatic breast cancer: A prospective observational study. Breast Cancer Res 2012;14:R29.
Falzarano R, Viggiani V, Michienzi S, Longo F, Tudini S, Frati L, et al
. Evaluation of a CLEIA automated assay system for the detection of a panel of tumor markers. Tumour Biol 2013;34:3093-100.
Yasasever V, Dinçer M, Camlica H, Karaloğlu D, Dalay N. Utility of CA 15-3 and CEA in monitoring breast cancer patients with bone metastases: Special emphasis on “spiking” phenomena. Clin Biochem 1997;30:53-6.
Thompson JA, Grunert F, Zimmermann W. Carcinoembryonic antigen gene family: Molecular biology and clinical perspectives. J Clin Lab Anal 1991;5:344-66.
Gendler SJ. MUC1, the renaissance molecule. J Mammary Gland Biol Neoplasia 2001;6:339-53.
Roy LD, Sahraei M, Subramani DB, Besmer D, Nath S, Tinder TL, et al
. MUC1 enhances invasiveness of pancreatic cancer cells by inducing epithelial to mesenchymal transition. Oncogene 2011;30:1449-59.
Wang W, Xu X, Tian B, Wang Y, Du L, Sun T, et al
. The diagnostic value of serum tumor markers CEA, CA19-9, CA125, CA15-3, and TPS in metastatic breast cancer. Clin Chim Acta 2017;470:51-5.
Jones LW, Alfano CM. Exercise-oncology research: Past, present, and future. Acta Oncol 2013;52:195-215.
Brenner DR, Neilson HK, Courneya KS, Friedenreich CM. Physical activity after breast cancer: Effect on survival and patient-reported outcomes. Curr Breast Cancer Rep 2014;6:193-204.
Fedewa MV, Hathaway ED, Ward-Ritacco CL, Williams TD, Dobbs WC. The effect of chronic exercise training on leptin: A systematic review and meta-analysis of randomized controlled trials. Sports Med 2018;48:1437-50.
Daley AJ, Crank H, Mutrie N, Saxton JM, Coleman R. Determinants of adherence to exercise in women treated for breast cancer. Eur J Oncol Nurs 2007;11:392-9.
Mazzarino M, Kerr D, Wajswelner H, Morris ME. Pilates method for women's health: Systematic review of randomized controlled trials. Arch Phys Med Rehabil 2015;96:2231-42.
Wells C, Kolt GS, Bialocerkowski A. Defining Pilates exercise: A systematic review. Complement Ther Med 2012;20:253-62.
Cramer H, Lauche R, Langhorst J, Dobos G. Yoga for depression: A systematic review and meta-analysis. Depression Anxiety 2013;30:1068-83.
Ghasemi Mobarekeh B, Vismeh Z, Parsa Gohar N. Effect of 12 weeks of selected Pilates exercise training on serum adiponectin level and insulin resistance in female survivors of breast cancer and its role in prevention of recurrence. Sci J Kurdistan Univ Med Sci 2015;20:61-73.
Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 2007;39:175-91.
Mutrie N, Campbell AM, Whyte F, McConnachie A, Emslie C, Lee L, et al
. Benefits of supervised group exercise programme for women being treated for early stage breast cancer: Pragmatic randomised controlled trial. BMJ 2007;334:517.
Matthews CE, Wilcox S, Hanby CL, Der Ananian C, Heiney SP, Gebretsadik T, et al
. Evaluation of a 12-week home-based walking intervention for breast cancer survivors. Support Care Cancer 2007;15:203-11.
Milne HM, Wallman KE, Gordon S, Courneya KS. Effects of a combined aerobic and resistance exercise program in breast cancer survivors: A randomized controlled trial. Breast Cancer Res Treat 2008;108:279-88.
Neilson HK, Friedenreich CM, Brockton NT, Millikan RC. Physical activity and postmenopausal breast cancer: Proposed biologic mechanisms and areas for future research. Cancer Epidemiol Biomarkers Prev 2009;18:11-27.
Ahima RS, Osei SY. Leptin signaling. Physiol Behav 2004;81:223-41.
Sweeney G. Leptin signalling. Cell Signal 2002;14:655-63.
Ishikawa M, Kitayama J, Nagawa H. Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer. Clin Cancer Res 2004;10:4325-31.
Miyoshi Y, Funahashi T, Tanaka S, Taguchi T, Tamaki Y, Shimomura I, et al
. High expression of leptin receptor mRNA in breast cancer tissue predicts poor prognosis for patients with high, but not low, serum leptin levels. Int J Cancer 2006;118:1414-9.
Karami L, Nuri R, Moghadasi M, Tahmasebi S, Taleie A. The effect of 12 weeks of walking on plasma levels of leptin in postmenopausal women with breast cancer. J Sport Biosci 2011;3:107-121.
Khajehlandi M, Bolboli L, Siahkuhian M, Nikseresht F. Effect of pilates training on serum levels of adiponectin and leptin in inactive women with overweight. J Jiroft Univ Med Sci 2018;4:201-12.
Travier N, Buckland G, Vendrell JJ, Fernandez-Veledo S, Peiró I, Del Barco S, et al
. Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors. Eur J Cancer Care (Engl) 2018;27:e12861.
Khoramjah M, Khorshidi D, Karimi M. Effect of moderate-intensity aerobic training on some hormonal and metabolic factors associated with breast cancer in overweight postmenopausal women. Salmand Iran J Age 2019;14:74-83.
Gronesova P, Cholujova D, Kozic K, Korbuly M, Vlcek M, Penesova A, et al
. Effects of short-term Pilates exercise on selected blood parameters. Gen Physiol Biophys 2018;37:443-51.
Dieli-Conwright CM, Courneya KS, Demark-Wahnefried W, Sami N, Lee K, Buchanan TA, et al
. Effects of aerobic and resistance exercise on metabolic syndrome, sarcopenic obesity, and circulating biomarkers in overweight or obese survivors of breast cancer: A randomized controlled trial. J Clin Oncol 2018;36:875-83.
Bruno E, Roveda E, Vitale J, Montaruli A, Berrino F, Villarini A, et al
. Effect of aerobic exercise intervention on markers of insulin resistance in breast cancer women. Eur J Cancer Care (Engl) 2018;27:e12617.
Motahari-Tabari N, Ahmad Shirvani M, Shirzad-E-Ahoodashty M, Yousefi-Abdolmaleki E, Teimourzadeh M. The effect of 8 weeks aerobic exercise on insulin resistance in type 2 diabetes: A randomized clinical trial. Glob J Health Sci 2014;7:115-21.
Schmidt S, Monk J, Robinson L, Mourtzakis M. The integrative role of leptin, oestrogen and the insulin family in obesity-associated breast cancer: Potential effects of exercise. Obes Rev 2015;16:473-87.
[Table 1], [Table 2], [Table 3], [Table 4]