|Year : 2021 | Volume
| Issue : 2 | Page : 67-73
The effect of aromatherapy with lavender essential oil on sleep quality in patients with major depression
, Yadollah Jannati1
, Angela Hamidia2, Reza Ali Mohammadpour3, Ali Hesamzadeh4
1 Department of Psychiatric Nursing, Nasibeh Faculty of Nursing and Midwifery, Mazandaran University of Medical Sciences, Sari, Iran
2 Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
3 Department of Biostatistics, Health Sciences Research Center, Addiction Institute, Medical School, Mazandaran University of Medical Sciences, Sari, Iran
4 Department of Community Health Nursing, Behshahr Faculty of Nursing, Mazandaran University of Medical Sciences, Sari, Iran
|Date of Submission||25-Apr-2020|
|Date of Decision||01-Jun-2020|
|Date of Acceptance||29-Dec-2020|
|Date of Web Publication||04-May-2021|
Dr. Yadollah Jannati
Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari
Source of Support: None, Conflict of Interest: None
Context: Depression is one of the most common psychiatric disorders, and poor sleep quality is a risk factor for it.
Aims: This study aimed at determining the effect of aromatherapy with lavender essential oil on sleep quality of patients with major depression.
Settings and Design: This single-blinded randomized clinical trial in Psychiatric Clinic in Yahya Nejad Hospital, Babol, Iran, during 2019.
Materials and Methods: Eighty major depressive patients with sleep disorder were recruited from those referred to Psychiatric Clinic in Babol City, Iran. They were assigned into intervention and control groups (forty participants in each group). The intervention group inhaled lavender essential oil and the control group received almond oil as placebo. Sleep quality of the participants was measured before and after the intervention.
Statistical Analysis Used: Data analysis was performed employing statistical tests including Chi-square, Kolmogorov–Smirnov, ANCOVA, independent t-test, and paired t-test.
Results: The intervention and control groups were homogeneous in terms of demographic characteristics and the mean score of sleep quality before the intervention (P > 0.05). The patients in the intervention group had a better quality of sleep comparing to that in the control group, and the difference was statistically meaningful (P = 0.001).
Conclusion: Aromatherapy with lavender essential oil has positive effects on sleep quality in depressed patients. It can be used as a noninvasive complementary method to improve sleep quality in patients with major depression.
Keywords: Aromatherapy, Depression, Herbal medicine, Lavender essential oil, Sleep quality
|How to cite this article:|
Samadi Z, Jannati Y, Hamidia A, Mohammadpour RA, Hesamzadeh A. The effect of aromatherapy with lavender essential oil on sleep quality in patients with major depression. J Nurs Midwifery Sci 2021;8:67-73
|How to cite this URL:|
Samadi Z, Jannati Y, Hamidia A, Mohammadpour RA, Hesamzadeh A. The effect of aromatherapy with lavender essential oil on sleep quality in patients with major depression. J Nurs Midwifery Sci [serial online] 2021 [cited 2021 Oct 18];8:67-73. Available from: https://www.jnmsjournal.org/text.asp?2021/8/2/67/315419
| Introduction|| |
Depression is a global health problem and the leading cause of inability and mental diseases. Depression leads to mental and physical tensions in individuals and society and results in declined life of quality, disability, and even death. It is estimated that the prevalence of depression in general population is between 15% and 25%. Similarly, about 15%–25% of the population in Iran suffers from mild-to-severe depression. One of the well-known features of depression is sleep disorder, that is, frequent unfavorable changes in sleep such as trouble in falling asleep, maintaining asleep, and early wake-up in the morning., These symptoms can be seen in 75% of the depression patients. There is a reciprocal relationship between depression and sleep quality disorder; low sleep quality is a great risk factor for depression and vice versa. Sleep quality is a subjective measure related to sleep experience consisting of sleep satisfaction and feeling fresh upon awakening. It consists of factors such as sleep quality, sleep onset latency, sleep duration, sleep efficiency, sleep disturbances, use of sleeping medications, and daytime dysfunction. Due to widespread sleep complaints and sleep inadequacy, sleep quality is of great importance as a measure for many diseases impact on the health. Its relationship with suicide occurrence makes it more important in depressive patients.
There are various treatment for sleep disorder, and sleeping medications such as benzodiazepines are considered as the first-line treatment and a safe drug group, though they are not advised for insomnia treatment for long time due to chance addiction. Moreover, benzodiazepines have some side effects such as prolonged sleep period with low sleep quality, symptoms of sleep discontinuation at abrupt stoppage, and sometimes it aggravates the sleep disorder. Therefore, complementary medicine, which is a safe, economic, and easy treatment with few side effects, has been employed as a priority in many treatment centers and nursing care units.
Depression is among the top ten, for which complementary medicine is used. For example, it is used for the treatment of about 53.6% of patients with depression in the United States. Aromatherapy is an alternative medicine which has been increasingly used in comparison to other medications during the recent years. It has also been extensively used for depression., Aromatherapy is the use of volatile oils or extracted essence from fragrant plants to prevent or help relieve patients, decrease the life problems, and improve the quality of life by influencing the mind, body, and soul. These oils are used and absorbed through massages, compresses, baths, inhaling, essential oil capsules, and food or medication spices.,,, One of the volatile fragrant plant oils which has been used in aromatherapy in traditional medicine is the lavender essential oil. Lavender is an herbaceous perennial aromatic plant in the mint family, Lamiaceae, having antifungal, antibacterial, laxative, antibloating, and sedative properties. It mostly consists of linalool and linaloyl acetate. Linalool is a tranquilizer affecting gamma-aminobutyric acid receptors in the central nervous system, whereas linaloyl acetate has narcotic effects. Some studies have been done on the effect of lavender essence aromatherapy on sleep quality and found that it has positive effects on sleep quality,,,,, However, some other research have demonstrated that aromatherapy with lavender essence has no effect on sleep quality of intensive care unit (ICU) patients and angiography candidates.,
Although herbs have been used to treat different types of diseases according to traditional medicine, scant information exists to approve their positive effects. Lavender is one of the plants assumed to have effects on depression symptoms, though no research was found to prove it. Therefore, this study aimed to determine the effects of aromatherapy with lavender essential oil on sleep quality of depressive patients.
| Materials and Methods|| |
Design study and sampling
In this single-blinded randomized clinical trial with pretest/posttest design, eighty major depressive patients with sleep disorder were recruited from those referred to Psychiatric Clinic in Yahya Nejad Hospital, Babol, Iran, from April to August 2019. Inclusion criteria included the following: giving written and oral informed consent, having age between 18 and 60 years, being literate, having sound smelling sensation, using Selective Serotonin Reuptake Inhibitors medications for <3 weeks, having the score of 10–17 in Hamilton Depression Rating Scale (HAMD-17), getting score 5 or more in Pittsburgh sleep quality index (PSQI). The exclusion criteria consisted of taking alcohol, being smoker, using opium, having allergic rhinitis, asthma, and respiratory diseases, using known traditional/alternative medicine that affects sleep quality, getting score of two or more from the suicide section of HAMD-17, having history of allergic to any aromatic material and lavender essential oil, having experience of unpredicted events (such as divorce, death of the close relative, travelling, and any other crisis) during the past 6 months, being hospitalized during intervention, being pregnant, having history of migraine or chronic headache, and being absent in the study for more than 3 days.
Sampling was done with 95% confidence interval with 5% margin of error according to the findings of the study conducted by Lee et al. Therefore, 34 participants were supposed to be in each group. Given to 10% probability of attrition, forty individuals were recruited in each group. First, 105 depressed patients referring to the clinic were selected according to convenience sampling method. Then, eighty eligible patients were assigned into intervention and control groups according to age (two age groups of 18–40 and 41–60) [Chart 1].
The researcher explained the research purposes and the procedures to participants. Then, they were allocated in the intervention group or the control group, randomly. Therefore, they were arranged to blocks of 4 and each group consisted of four individuals in six conditions (AABB, BBAA, ABAB, BABA, ABBA, and BAAB). Each participant was designated as A (aromatherapy) or B (placebo). Both groups were taught how to do aromatherapy each night based on their sleep pattern. They were asked to do it 1 h before sleeping between 21:00 and 24:00 in bed in a dark room with mild temperature, proper ventilation, and away from any fragrance or scent. Aromatherapy continued for 14 consecutive nights with 10% lavender essential oil (Barij Essence Pharmaceutic Corporation, Kashan, ISO 9001, ISO/IEC1725)., The participants were asked to stain a 2 cm × 2 cm cotton gauze with two drops of lavender essential oil and fix it to their collars with 20 cm distance from their nose and breathe naturally. Then, they had to detach it in the morning as soon as they wake up., The dilute base dissolution of the lavender was almond essential oil.
The control group used almond essential oil (Barij Essence Pharmaceutic Corporation) as the placebo for aromatherapy. The researcher made telephone call the participants every 2 days to control intervention procedure.
The study tools included demographic information questionnaire (age, gender, marital status, graduation, occupation, residence, known underlying disorders, and history of depression), PSQI which was completed before the intervention and 1 day after the intervention by all the participants and HAMD-17 to assess the depression severity. A score of 0–9 is considered normal, a score between 10 and 13 indicates mild depression, a score between 14 and 17 is related to those with moderate depression, while the score higher than 17 indicates severe depression., Reliability coefficient and validity of this index in the Iranian version is 85% and 89%, respectively., Cronbach's alpha in this study was calculated as 82%.
To assess sleep quality of the participants, PSQI was applied as a standard questionnaire for determining self-reported sleep quality within the last month. This questionnaire consists of nine questions in seven components (subjective sleep quality, sleeps onset latency, sleep duration, sleep efficiency, sleep disturbances, use of sleeping medications, and daytime dysfunction). The global PSQI score ranges from 0 to 21. Each component in the questionnaire has a score of 0–3 (0 showing good condition, 1 for almost a good condition, 2 shows almost bad condition, and 3 is used for bad condition). The higher the score is, the worse the sleep quality will be. A score smaller than 5 shows good quality of sleep, while a score of 5 and greater indicates undesirable sleep quality. The validity of PSQI has been approved in Iranian population with a sensitivity of 10%, specificity of 93%, and Cronbach's alpha of 89%. In this study, Cronbach' alpha was found to be 72%, showing an acceptable internal consistency.
The Ethics Committee of Mazandaran University of Medical Sciences approved the study (REC. MAZUMS.1397.2701). This research was registered in the Iranian Registry of Clinical Trials (IRCT20180924041109N2). All participants signed consent form to participate in the study. The necessary information on the objectives, background, and methods of the intervention was provided to the participants. They were also ensured that their personal information would be kept secret. Moreover, the participants were informed that they can leave the intervention whenever they decide without any possible negative consequences.
To examine the normality of the data distribution, Kolmogorov–Smirnov test was employed, and to determine the homogeneity of the groups and omitting the confounding variables before the intervention, ANCOVA test was utilized. Data were analyzed by SPSS version 23 (SPSS Inc., Chicago, IL) using descriptive statistics of mean and standard deviation, and inferential statistics of Chi-square, independent t-test, and paired t-test. P value of smaller than 0.05 was considered significance level.
| Results|| |
The participants' age ranged from 18 to 60, 50% of them in each group were between 18 and 40 years and 50% were 41–60 years. Among those in the intervention group, 70% had reported moderate fatigue and 30% complaint of severe fatigue. In contrast, 72.5% of those who were allocated in the control group reported moderate fatigue and 22.5% complaint of severe fatigue. Both groups were homogeneous regarding demographic information and fatigue severity, and the difference was not statistically significant [Table 1].
|Table 1: Demographic information of the participants in intervention and control groups|
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Kolmogorov–Smirnov test displayed a normal distribution for sleep quality variable; therefore, parametric tests were employed for statistical analysis (P > 0.05). Independent t-test revealed that no significant difference could be observed between the two intervention and control groups before the intervention (P = 0.12). However, after the intervention, the mean score of the sleep quality in the intervention group was 12.27 ± 2.11 and in the control group was 15.60 ± 2.36. The patients in the intervention group had a better quality of sleep comparing to that in the control group, and the difference was statistically meaningful (P = 0.001). Paired t-test indicated a significant difference between the sleep quality of the intervention group before and after the intervention (P = 0.001), as well, while in the control group, the difference was not statistically significant (P = 0.14) [Table 2].
|Table 2: Comparing the mean and standard deviation of sleep quality before and after the intervention in both intervention and control groups|
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To determine the homogeneity of the groups and eliminating the confounding variable before the intervention, ANCOVA test was utilized. After adjusting pretest scores, there was a within-group significance (F = 103.451) with significance level of P = 0.001 (P < 0.05). It was revealed that the mean score was significantly higher among the sleep quality of the intervention group in comparison to those allocated in the control group. Moreover, the square Eta (0.45) indicated a strong relationship between aromatherapy (independent variable) and sleep quality (dependent variable), in other words, about 45% of the sleep quality variance is explained by aromatherapy [Table 3].
|Table 3: ANCOVA for investigating the effects of aromatherapy on sleep quality by eliminating the effect of pretest in intervention group and control group|
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| Discussion|| |
The findings revealed that aromatherapy with lavender essential oil for 2 weeks brought about improvement in sleep quality of patients with depression. Chien and coll. (2012) revealed that the total score of sleep quality increased among the intervention group that had smelled lavender essential oil in comparison to the study onset, whereas no difference was observed in the control group during the same period. The study conducted by Stevens et al. showed that herbal supplement containing lavender essential oil was effective on the several mental parameters of sleep quality among the participants with mild-to-moderate insomnia. Although the findings are in agreement with that of our study, they used lavender oral capsule for healthy adults, while we worked on depressed patients who smelled lavender essential oil. Muz and Taşcı, conducted a study to investigate the effect of aromatherapy on the sleep quality and fatigue of hemodialysis patients. The intervention group received the intervention containing aromatherapy with lavender essential oil and sweet tangerine every night before sleeping during 1 month. On the other hand, those in the control group just received the routine treatment. The findings indicated that aromatherapy improved the sleep quality and fatigue in hemodialysis patients, which is compatible with the present research. A study conducted by Lee et al. investigated the effect of aromatherapy on sleep disorder, sleep satisfaction, and fatigue among hemodialysis patients, it was revealed that aromatherapy with lavender lessened the fatigue and increased the sleep satisfaction in these patients, which is consistent with the present study results. Karadag et al. performed a research aiming at probing the effect of lavender on sleep quality and anxiety of patients hospitalized in ICU. The intervention group received aromatherapy with two drops of lavender essential oil before sleeping. The control group received nothing. Sleep quality and anxiety of the patients were assessed after 15 days. The findings revealed that lavender essential oil leads to improvement in sleep quality and decreases the anxiety of the patients with coronary artery disease, which is line with the present study findings. Najafi et al. conducted a study to find out whether lavender essential oil affects the sleep quality of hemodialysis patients. The intervention group received lavender aromatherapy for 7 days. The findings indicated that aromatherapy with lavender essential oil led to improvement on the sleep quality of the hemodialysis patients and can be used as a cheap, easy, and noninvasive method for treating sleep disorders in patients. The abovementioned study results are also compatible with the present study findings. Otaghi et al. worked on the effect of lavender essential oil on the sleep quality of angiography candidates in cardiac care unit. The results revealed that lavender essential oil did not have any effects on the patients' sleep quality, which is not compatible with the present study and can be due to the different research population and data collection tools. Park et al. also conducted a study to investigate the effect of aroma hand massage technique on the fatigue and sleep quality of the patients. Lavender essential oil and 1% bergamot were rubbed to each hand of the patient for 5 min before sleep. The findings showed that the intervention did not have any significant effect on fatigue lessened and sleep quality, which is not in line with the present study findings and it can be due to the different methodology. Shamsikhani et al. conducted a study to investigate the effect of aromatherapy with lavender essential oil on sleep quality of the nursing students. The results revealed that there was not any significant improvement in the sleep quality of the students. The finding is not in line with the findings of our study which may be because of different statistical population and different methodology.
As the intervention was done in the patients' home, some factors (such as environmental sounds) might have affected the participants' sleep quality. Moreover, the patients' sleep habits can affect their sleep quality that could not be controlled.
| Conclusion|| |
The findings of this study revealed that aromatherapy with lavender essential oil improves the sleep quality of depressed patients. Therefore, it can be used as a cheap and easy method in patients with mild-to-moderate depression who frequently suffer sleep disorder. It seems that this method can be used as a complementary treatment for medical treatments such as hypnotic drugs with high side effects for the patients with mild-to-moderate depression.
Conflicts of interest
There are no conflicts of interest.
Z.S designed, carried out the experiment and wrote manuscript with scientific support from Y.J., Angela H., R. M. And Ali H.Moreover Y.J., Angela H. R. M. And Ali H. supervised the project. Y.J and Z.S. conceived the original idea. Angela H. contributed to sample preparation. R.M performed analyzing data.
Financial support and sponsorship
The research project was financially supported by the Deputy of research and Technology of Mazandaran University Medical Sciences, Sari, Iran.
This paper was confirmed in the Ethics Committee for Biomedical of Mazandaran University of Medical Sciences under the code of IR.MAZUMS.REC1397.27.1. It was also registered in Clinical Trials Center (http://www.irct.ir) with registry number of IRCT20180924041109N2. We are showing our gratitude to Mazandaran University of Medical Sciences for funding this research.
| References|| |
Sohrabi A, Mahmoudi H, Salamezadeh Zavareh E, Siratinir M. Effect of cardiopulmonary resuscitation training based on stabilizing model on depression, anxiety and stress of intensive care unit nurses. Educ Strateg Med Sci 2014;7:83-8.
Shamsikhani S, Farmahini Farahani M, Shamsikhani S, Sobhani M. Effectiveness of problem solving training on depression in nursing student. Int J Palliat Nurs 2014;2:63-71.
Mousavinejad N. Impact of cognitive skills training on reducing depression among clients during pregnancy & postpartum referring to health centers. Iran J Health Educ Health Promot 2015;3:39-48.
Berlim MT, McGirr A, Fleck MP. Can sociodemographic and clinical variables predict the quality of life of outpatients with major depression? Psychiatry Res 2008;160:364-71.
Poole L, Jackowska M. The epidemiology of depressive symptoms and poor sleep: Findings from the English Longitudinal Study of Ageing (ELSA). Int J Behav Med 2018;25:151-61.
Chang PP, Ford DE, Mead LA, Cooper-Patrick L, Klag MJ. Insomnia in young men and subsequent depression. The johns Hopkins precursors study. Am J Epidemiol 1997;146:105-14.
Rabiei Z, Rabiei S. A review on antidepressant effect of medicinal plants. Banglad J Pharmacol 2017;12:1-11.
Skapinakis P, Rai D, Anagnostopoulos F, Harrison S, Araya R, Lewis G. Sleep disturbances and depressive symptoms: An investigation of their longitudinal association in a representative sample of the UK general population. Psychol Med 2013;43:329-39.
Dewald JF, Meijer AM, Oort FJ, Kerkhof GA, Bögels SM. The influence of sleep quality, sleep duration and sleepiness on school performance in children and adolescents: A meta-analytic review. Sleep Med Rev 2010;14:179-89.
Backhaus J, Junghanns K, Broocks A, Riemann D, Hohagen F. Test-retest reliability and validity of the Pittsburgh sleep quality index in primary insomnia. J Psychosom Res 2002;53:737-40.
Amrollahi A, Salimi T, Farnia F, Lotfi MH. Comparison of the effects of aromatherapy with lavender essential oil and musictherapy on sleep quality of burned patients. Complement Med J 2016;6:1490-9.
Baune B, Caliskan S, Todder D. Effects of adjunctive antidepressant therapy with quetiapine on clinical outcome, quality of sleep and daytime motor activity in patients with treatment-resistant depression. Hum Psychopharmacol 2007;22:1-9.
Sarris J, Byrne GJ. A systematic review of insomnia and complementary medicine. Sleep Med Rev 2011;15:99-106.
Najafi Z, Tagharrobi Z, Shahriyari-Kale-Masihi M. Effect of aromatherapy with lavender on sleep quality among patients undergoing hemodialysis. Feyz 2014;18:145-50.
Ranani HA, Zamenjani MN, Asnafi AA, Latifi M. The effect of aromatherapy with orange essential oils on sleep quality in the school-age children whit ALL. Complement Med J 2015;5:1113-22.
Boostani H, Pakseresht S, Amani R, Nokhostin M, Haghdoost MR. Evaluation of Vitamin B-complex efficacy add on citalopram in outpatient with major depressive disorder Jundishapur Sci Med J 2011;9:605-12.
Yeung WF, Chung KF, Ng KY, Yu YM, Zhang SP, Ng BF, et al
. Prescription of Chinese herbal medicine in pattern-based traditional Chinese medicine treatment for depression: A systematic review. Evid Based Complement Alternat Med 2015;2015:160189.
Smith MC, Kyle L. Holistic foundations of aromatherapy for nursing. Holist Nurs Pract 2008;22:3-9.
Xiong M, Li Y, Tang P, Zhang Y, Cao M, Ni J, et al
. Effectiveness of aromatherapy massage and inhalation on symptoms of depression in Chinese community-dwelling older adults. J Altern Complement Med 2018;24:717-24.
Lytle J, Mwatha C, Davis KK. Effect of lavender aromatherapy on vital signs and perceived quality of sleep in the intermediate care unit: A pilot study. Am J Crit Care 2014;23:24-9.
Ghiasi A, Hasani M, Mollaahmadi L, Hashemzadeh M, Haseli A. The effect of aromatherapy on labor pain relief: A systematic review of clinical trials. Iran J Obstet Gynecol Infertil 2017;20:89-105.
Louis M, Kowalski SD. Use of aromatherapy with hospice patients to decrease pain, anxiety, and depression and to promote an increased sense of well-being. Am J Hosp Palliat Care 2002;19:381-6.
Perry N, Perry E. Aromatherapy in the management of psychiatric disorders: Clinical and neuropharmacological perspectives. CNS Drugs 2006;20:257-80.
Moghadam K, Farmahini Farahani M, Sajadi M, Sarmadian H, Norouzi Zamenjani M, Heydari H. Effect of aromatherapy with lavender on quality of sleep of nursing students. Complement Med J Nurs Midwifery 2015;17:33-42.
Shamsikhani S, Hekmat Pu D, Sajadi Hezaveh M, Shamsikhani S, Khorasani S, Behzadi F. Effect of aromatherapy with lavender on quality of sleep of nursing students. Complement Med J 2014;4:904-12.
Kasper S, Gastpar M, Müller WE, Volz H-P, Möller H-J, Dienel A, et al
. Silexan, an orally administered lavandula oil preparation, is effective in the treatment of 'subsyndromal' anxiety disorder: A randomized, double-blind, placebo controlled trial. Int Clin Psychopharmacol 2010;25:277-87.
Muz G, Taşcı S. Effect of aromatherapy via inhalation on the sleep quality and fatigue level in people undergoing hemodialysis. Appl Nurs Res 2017;37:28-35.
Pourmirzaie M, Teymouri F, Farsi z, Rajai N, Mousavi NM. The effects of inhaling lavender fragrance on hemodynamic indexes during sheath take out in patients after coronary angiography in a military hospital. J Mil Caring Sci 2017;4:30-8.
Cho MY, Min ES, Hur MH, Lee MS. Effects of aromatherapy on the anxiety, vital signs, and sleep quality of percutaneous coronary intervention patients in intensive care units. Evid Based Complement Alternat Med 2013;2013:381381.
Otaghi M, Qavam S, Norozi S, Borji M, Moradi M. Investigating the effect of lavender essential oil on sleep quality in patients candidates for angiography. Biomed Pharmacol J 2017;10:473-8.
Park H, Chun Y, Kwak S. The effects of aroma hand massage on fatigue and sleeping among hospice patients. Open J Nurs 2016;6:515-23.
Lee EJ, Kim BS, Sa IH, Moon KE, Kim JH. The effects of aromatherapy on sleep disorders, satisfaction of sleep and fatigue in hemodialysis patients. Korean J Adult Nurs 2011;23:615-23.
Farhud D, Tahavorgar A. Melatonin hormone, metabolism and its clinical effects: A review. Iran J Endocrinol Metab 2013;15:211-23.
Laekeman G. Assessment Report on Lavandula Angustifolia Miller, Aetheroleum and Lavandula Angustifolia Miller, flos: EMA/HMPC/143183/2010 Committee on Herbal Medicinal Products (HMPC); 2012.
Karadag E, Samancioglu S, Ozden D, Bakir E. Effects of aromatherapy on sleep quality and anxiety of patients. Nurs Crit Care 2017;22:105-12.
Gerbasi ME, Eldar-Lissai A, Acaster S, Fridman M, Bonthapally V, Hodgkins P, et al
. Associations between commonly used patient-reported outcome tools in postpartum depression clinical practice and the Hamilton Rating Scale for Depression. Arch Womens Ment Health 2020;23:727-35.
Mirabdolhagh Hazaveh M, Dormohammadi Toosi T, Nasiri Toosi M, Tavakoli A, Shahbazi F. Prevalence and severity of depression in chronic viral hepatitis in Iran. Gastroenterol Rep (Oxf) 2015;3:234-7.
Ebrahimi A, Neshatdoost HT, Mousavi SG, Asadollahi GA, Nasiri H. Controlled randomized clinical trial of spirituality integrated psychotherapy, cognitive-behavioral therapy and medication intervention on depressive symptoms and dysfunctional attitudes in patients with dysthymic disorder. Adv Biomed Res 2013;2:53. [Full text]
Arab Z, Shariati A, Bahrami H, Asayesh H, Vakili M. The effect of acupressure on quality of sleep in hemodialysis patients. Nurs Midwifery J 2012;10:237-46.
Chien LW, Cheng SL, Liu CF. The effect of lavender aromatherapy on autonomic nervous system in midlife women with insomnia. Evid Based Complement Alternat Med 2012;2012:740813.
Stevens N, Dorsett J, DaBell A, Eggett DL, Han X, Parker TL. Subjective assessment of the effects of an herbal supplement containing lavender essential oil on sleep quality: A randomized, double-blind, placebo-controlled crossover study. Cogent Med 2017;4:1-11.
[Table 1], [Table 2], [Table 3]