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Year : 2015  |  Volume : 2  |  Issue : 4  |  Page : 70-74

Alobar holoprosencephaly: A case report

1 Faculty of Nursing & Midwifery, Zabol University of Medical Sciences, Zabol, Iran
2 Nursing Research Center, Golestan University of Medical Sciences, Golestan, Iran
3 Faculty of Medical Sciences Khomain, Arak University of Medical Sciences, Arak, Iran
4 University of Medical Sciences, Tehran, Iran
5 Zahedan University of Medical Sciences, Zahedan, Iran

Correspondence Address:
Leila Mirshekari
Faculty of Nursing & Midwifery, Zabol University of Medical Sciences, Zabol
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Source of Support: None, Conflict of Interest: None

DOI: 10.18869/acadpub.jnms.2.4.70

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Holoprosencephaly (HPE) is a rare congenital brain malformation associated with multiple midline facial defects. This anomaly is resulted from the failure of diverticulation and cleavage of primitive prosencephalon during weeks 4-8 of gestation. HPE is the most common forebrain developmental anomaly in human with the incidence rate of 0.49-1.2 cases per 10,000-20,000 term births. In this study, we described a case of HPE in a neonate with gestational age of 32 weeks. Antenatal ultrasonographic diagnosis was performed, and the infant was presented with macrocephaly, bilateral microphthalmia, hypotelorism, proboscis and ambiguous genitalia.

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